Bmp2 overexpression effects over appendicular skeleton development

Histomorphological Variation in the Appendicular Skeleton

Densities of osteons and osteon fragments at the midshafts of the femur, tibia, fibula, humerus, radius, ulna and clavicle are examined in a sample of contemporary human males and females (n = 39; 23 female, 16 male), with comparative data derived from one specimen each of Gallus gallus and Felis silvestris catus. Results demonstrate that there are significant differences in mean complete and f...

Burkitt's lymphoma in the appendicular skeleton.

Of 290 Ugandan children and adolescents with proven Burkitt's lymphoma 11 had lesions in the long bones or the pelvis. These started in the medulla as small osteolytic foci which coalesced and penetrated the cortex causing subperiosteal new bone formation in layers or spicules, and giving rise to large soft-tissue masses. Common sites were the femoral and tibial diaphyses and the metaphyses aro...

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development.

The role of Notch signaling in cartilage differentiation and maturation in vivo was examined. Conditional Notch pathway gain and loss of function was achieved using a Cre/loxP approach to manipulate Notch signaling in cartilage precursors and chondrocytes of the developing mouse embryo. Conditional overexpression of activated Notch intracellular domain (NICD) in the chondrocyte lineage results ...

Endochondral bone formation and development in the axial and appendicular skeleton

MRI of enthesitis of the appendicular skeleton in spondyloarthritis.

Entheses are sites where tendons, ligaments, joint capsules or fascia attach to bone. Inflammation of the entheses (enthesitis) is a well-known hallmark of spondyloarthritis (SpA). As entheses are associated with adjacent, functionally related structures, the concepts of an enthesis organ and functional entheses have been proposed. This is important in interpreting imaging findings in entheseal...